Rivaroxaban (BAY 59-7939) is an oral anticoagulant invented and manufactured by Bayer;in a number of countries it is marketed as Xarelto. In the United States, it is marketed by Janssen Pharmaceutica. It is the first available orally active direct factor Xa inhibitor. Rivaroxaban is well absorbed from the gut and maximum inhibition of factor Xa occurs four hours after a dose. The effects last approximately 8–12 hours, but factor Xa activity does not return to normal within 24 hours so once-daily dosing is possible.
Medical uses
In those with non-valvular atrial fibrillation it appears to be as effective as warfarin in preventing nonhemorrhagic strokes and embolic events. Rivaroxaban is associated with lower rates of serious and fatal bleeding events than warfarin though rivaroxaban is associated with higher rates of bleeding in the gastrointestinal tract.
Details
CAS Number:366789-02-8
Name:2-Thiophenecarboxamide,5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-
Superlist Name:Rivaroxaban
Formula:C19H18ClN3O5S
Molecular Weight:435.88
Synonyms:5-Chloro-N-[[(S)-3-(4-(3-oxomorpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]-thiophene-2-carboxamide;BAY 59-7939;Xarelto;
Density:1.46 g/cm3
Boiling Point:732.609 °C at 760 mmHg
Flash Point:396.868 °C
Specifications:
| Items | Standard | Results |
| Appearance | White or almost white powder | White powder |
| Melting point | 229~ 234℃ | 230.0~231.5℃ |
| Residue on ignition | NMT0.1% | 0.03% |
| Related substances | Any other impurity: NMT0.2%Total of impurity: NMT0.5 % | 0.1%0.19% |
| Loss on drying | NMT1.0% | 0.13% |
| Heavy metal | NMT20ppm | Conforms |
| Purity | More than 99.50% | 99.81% |
| Conclusion: The results show that the product complies withthe Enterprise standard. | ||
Introduction:
Antithrombotic drugs
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